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Wishbone PDF
By:Laura C. Jarmon
Published on 2003 by Univ. of Tennessee Press

Wishbone: Reference and Interpretation in Black Folk Narrative follows African American folklore to its roots in African sources, bringing together a selection of narratives from both Africa and the United States and stressing their common bond and history. Laura C. Jarmon provides synopses of a number of African and African American folk tales, giving the reader a broad sample of tales with themes common to both cultures. Then, through analysis of form, language, and tone, she argues that black folk expression is modal, i.e., open-ended and tentative, a posture revealed in both the behavior and the discourse of the narratives' folk participants. By tracing the folklore to it's sources, Jarmon seeks to correct nineteenth-century suggestions that African American folklore must have its origin in European sources. The Author: Laura C. Jarmon is professor of English at the University of Tennessee, martin. She is coeditor of Thomas Talley's The Negro traditions (Tennessee), and author of Arbors to Bricks: A Hundred Years of African American Education in Rutherford County, Tennessee, 1865-1965. She lives in Stanton, Tennessee.

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Time, Tense, and Reference PDF
By:Aleksandar Jokić,Quentin Smith
Published on 2003 by MIT Press

Original essays by philosophers of language and philosophers of time exploring the semantics and metaphysics of tense.

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Pharmacokinetics in Drug Development PDF
By:Peter L. Bonate,Danny R. Howard
Published on 2016-10-06 by Springer

In this volume, the specific challenges and problems facing the evaluation of new oncology agents are explored with regards to pharmacokinetic, pharmacodynamic modeling and clinical pharmacology development strategies. This book delivers, with an emphasis on the oncology therapeutic area, the goals set in the first three volumes: namely – to provide clinical pharmacologists practical insights for the application of pharmacology, pharmacokinetics and pharmacodynamics for new drug development strategies. Pharmacokinetic-pharmacodynamic concepts for tyrosine kinases, the evaluation of cardiac repolarization prolongation through QTc interval effects, efficacy- and safety-response analyses to support new drug approvals, clinical and preclinical tumor growth modeling, and flat- vs weight-based dose selection are showcased from an oncology clinical pharmacologist’s point-of-view. Oncology development strategies are surveyed for new FDA-approvals to identify patterns in expectations at time of first approval. The special considerations necessary to address combination drug development, metronomics, biosimilars and breakthrough therapies are also presented.

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Human Insulin PDF
By:D.R. Owens
Published on 2012-12-06 by Springer Science & Business Media

Since insulin became available for the treatment of diabetes in 1922 a number of major advances have been made, which include the modification of insulin to vary its timing of action, its purification, and latterly, the production of human insulin. Human insulin in quantities sufficiently large for therapy has been made available by two techniques developed in parallel during the late 1970s. These involve either (i) formulation in E. coli bacteria suitably encoded by DNA recombinant methods of the A- and B-chains of human insulin followed by a chain combination reaction ('biosynthetic' human insulin) or (ii) enzymatic conversion (transpeptidation) of porcine insulin brought to react with a threonine ester by porcine trypsin in a mixture of water and organic solvents, yielding human insulin ('semi-synthetic' human insulin). This book includes the first clinical-pharmacological studies of each of the highly purified 'semi-synthetic' human insulin preparations: Actrapid ® HM; Monotard® HM; Protaphane® HM; Actraphane® HM; and Ultratard® HM (Novo Industri A/S, Copenhagen). The preliminary studies established their safety and efficacy relative to their porcine and bovine counterparts emphasising the relevance of species and formulation on the pharmacokinetics and biological responses to insulin. Additional investigations with human insulin demonstrated the influence of insulin concentration, site of administration, the addition of aprotinin to insulin and the mixing of 'short-' and 'intermediate-acting' formulations on insulin 'bioavailability'. Examination of the 'within' and 'between' subject day-to-day variation in absorption and the effect of subcutaneous insulin also demonstrates the dominating influence of insulin responsiveness.

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Download A Pharmacokinetics and Pharmacodynamics (PK/PD) Guided Approach to Lead Optimization of Nitrofuranylamide Anti-tuberculosis Agents Books PDF Free

A Pharmacokinetics and Pharmacodynamics (PK/PD) Guided Approach to Lead Optimization of Nitrofuranylamide Anti-tuberculosis Agents PDF
By:Nageshwar Rao Budha
Published on 2009 by

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Download Stereselective Synthesis, Pharmacodynamics and Pharmacokinetics of Chiral Amide Analogues of Valproic Acid Books PDF Free

Stereselective Synthesis, Pharmacodynamics and Pharmacokinetics of Chiral Amide Analogues of Valproic Acid PDF
By:Ofer Spiegelstein
Published on 1999 by

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Download ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins Books PDF Free

ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins PDF
By:Honghui Zhou,Frank-Peter Theil
Published on 2015-12-02 by John Wiley & Sons

|This book focuses on the fundamental and practical aspects of ADME and translational PK/PD for therapeutic proteins -- cutting-edge research, lessons learned from small molecules, the utility of ADME and translational PK/PD to guide lead optimization, first-in-human study dose projection and design, and clinical development and registration|--Provided by publisher.

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Download Partnership Law Books PDF Free

Partnership Law PDF
By:Great Britain. Law Commission
Published on by

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Kylix PDF
By:Jon Shemitz
Published on 2002 by

Shemitz's book serves as a comprehensive resource to all aspects of creating powerful Linux applications using the powerful new development platform of Kylix. Prefacing the core Kylix material with an accelerated introduction to Object Pascal, this volume will attract both novices and Delphi experts alike.

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The Politics of the Draft Common Frame of Reference PDF
By:Alessandro Somma
Published on 2009-01-01 by Kluwer Law International

This collection of essays reflects both the diversity of the group's work and the common thread that runs through it. The core claim here is that the DCFR, despite the Commission's characterization of its proposals as purely technical, cannot escape politics. The intent is to critically identify and evaluate the model of social justice underlying the DCFR.

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Download The Trees of Florida Books PDF Free

The Trees of Florida PDF
By:Gil Nelson
Published on 1994 by Pineapple Press Inc

* First comprehensive guide to Florida's amazing variety of trees. * Covers both natives & exotics. * Useful to the naturalist, professional botanist, landscape architect & weekend gardener. * Includes suggested field sites for observing the species described. * Line drawings by Marvin Cook show a combination of typical leaves, fruits & flowers. * Color photos where color is important in identification. Dr. Gil Nelson is the author of Exploring Wild North Florida & Exploring Wild Northwest Florida, also published by Pineapple Press. |Thick enough to be inclusive but compact enough to carry on a walk in the woods.|--Tallahassee Democrat. |Clear & useful to all levels of botanists...(with) some of the best photos of difficult to photograph plants. A welcome addition to the Florida field guide literature.|--Carol Lippincott, botanist.

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Natural Alternatives to Antibiotics PDF
By:John McKenna
Published on 1998 by Penguin

Dr. McKenna offers information on the herbal remedies, nutritional supplements, and dietary changes that can combat bacterial infections without the use of antibiotics.

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Proton Pump Inhibitors: A Balanced View PDF
By:T. Chiba,P. Malfertheiner,H. Satoh
Published on 2013-09-23 by Karger Medical and Scientific Publishers

The discovery of proton pump inhibitors (PPIs) and their development over the years has dramatically changed the management of acid-related diseases. Today, the therapeutic domain of PPIs ranges from relief of symptoms to cure of mucosal lesions in the upper gastrointestinal tract. PPIs are among the most widely sold drugs in the world and are now even available as over-the-counter medication. This publication presents the experience of the last 25 years during which PPIs have become of enormous value in gastroenterology. The authors provide an update on a variety of subjects, starting with an introduction to the discovery and development of PPIs. This is followed by chapters on pharmacokinetics, pharmacodynamics and pharmacogenetics, gastroesophageal reflux disease, gastroprotection, Helicobacter pylori eradication treatment, peptic ulcer disease, functional dyspepsia, acid suppression in exocrine pancreatic insufficiency, and gastrointestinal and systemic side effects. Readers who are interested in a current overview of PPIs and their various applications will find this book of great value.

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Download Pharmacokinetics and Pharmacodynamics of Antimalarial Drugs Used in Combination Therapy Books PDF Free

Pharmacokinetics and Pharmacodynamics of Antimalarial Drugs Used in Combination Therapy PDF
By:Qigui Li,Mark R. Hickman
Published on 2015-06-04 by Bentham Science Publishers

Malaria takes a great toll on human health and well-being, particularly in tropical regions including Sub-Saharan Africa, Southeast Asia, Oceania and parts of the Americas. In recent years, some Plasmodium strains have become increasingly resistant to all classes of conventional antimalarial drugs currently in use. Researchers have, therefore, stepped up efforts to revise atimalarial drug policies, develop new drugs, and implement new strategies to combat this disease. In order to prevent widespread resistance, antimalarial combination therapies (ACTs) have been deployed and a World Antimalarial Resistance Network has been established as a means of anitimalarial drug resistance surveillance. Artemisinin-based combination therapies have proven to be useful as a replacement for standard regimens. Currently, these ACTs successfully cure patients suffering from uncomplicated malaria with superior efficacy and lower toxicity, but there remains a huge challenge (high mortality rate) associated with treatment of severe malaria. Studies of drug disposition and drug efficacy (PK/PD evaluations) are essential to understanding why drugs work as antimalarials as they illustrate issues with drug resistance, drug safety and drug toxicity that are critical to finding the appropriate drug dose for patients. This eBook illustrates how currently available combination antimalarial drugs can be optimized for effective malaria treatment. Chapters in this book explain methods to select combination drugs based on PK/PD evaluations followed by methods o reduce drug toxicity based on these evaluations. The book also summarizes efforts that are being made by the research community to improve ACT. It is, therefore, a handy reference for medical professionals and pharmacologists working on antimalarial drugs.

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Soil Analysis Handbook of Reference Methods PDF
By:J. Benton Jones, Jr.
Published on 1999-12-20 by CRC Press

For more than 30 years, soil testing has been widely used as a basis for determining lime and fertilizer needs. Today, a number of procedures are used for determining everything from soil pH and lime requirement, to the level of extractable nutrient elements. And as the number of cropped fields being tested increases, more and more farmers and growers will come to rely on soil test results. But if soil testing is to be an effective means of evaluating the fertility status of soils, standardization of methodology is essential. No single test is appropriate for all soils. Soil Analysis Handbook of Reference Methods is a standard laboratory technique manual for the most commonly used soil analysis procedures. First published in 1974, this Handbook has changed over the years to reflect evolving needs. New test methods and modifications have been added, as well as new sections on nitrate, heavy metals, and quality assurance plans for agricultural testing laboratories. Compiled by the Soil and Plant Analysis Council, this latest edition of Soil Analysis Handbook of Reference Methods also addresses the major methods for managing plant nutrition currently in use in the United States and other parts of the world. For soil scientists, farmers, growers, or anyone with an interest in the environment, this reference will prove an invaluable guide to standard methods for soil testing well into the future. Features

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Download The Impact of Emerging Technologies on Reference Service and Bibliographic Instruction Books PDF Free

The Impact of Emerging Technologies on Reference Service and Bibliographic Instruction PDF
By:Gary M. Pitkin
Published on 1995 by Greenwood Publishing Group

Information technologies are having a profound impact on traditional library services and education. This book identifies emerging technologies and assesses their impact on reference service, bibliographic instruction, and organizational management. In addition. library education is discussed as a partner responsible for redesigning the curriculum and redefining the librarian of the future.

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The Government Contracts Reference Book PDF
By:CCH Incorporated,Ralph C. Nash,Ralph C. Nash, Jr.,Steven L. Schooner,Karen R. O'Brien-DeBakey
Published on 2013 by Aspen Publishers

Save time and eliminate errors with this quick-reference, A-Z guide to the language of procurement! Successful government contracting requires the use of precise, up-to-date terminology, as well as a firm understanding of current regulatory and case law. This quick-reference guide saves time and makes your job easier by providing ready definitions for more than 1500 terms, phrases and acronyms used in government procurement. Completely up-to-date terminology reflects statutory and regulatory changes, including some 600 terms relating directly to the rules and procedures mandated by various statutes and regulations, including: the Federal Acquisition Streamlining Act, the Clinger-Cohen Act, the Federal Acquisition Regulation and agency FAR supplements. Written by preeminent experts on government contracts, Ralph C. Nash, Jr., Karen O'Brien-DeBakey, and Steven L. Schooner, The Government Contracts Reference Book provides clear explanations for general terms related to government procurement, as well as agency-specific terms from the Department of Defense, General Services Administration, Department of Energy, other agencies. Each explanation includes a summary of where the term is used in the statutes or regulations, including citations to the source documents. Organized in an easy-to-use alphabetical format and fully cross-referenced, this essential reference will help you manage all aspects of the procurement process with greater efficiency and confidence. The ideal starting point for further research! When you need to explore a term or topic further, The Government Contracts Reference Book serves as an invaluable research tool. You'll find: Current citations to FAR, DFARS, DEAR, NFS and other regulations, as well as to pertinent statutes, federal court decisions, administrative board decisions, and other important material Frequent references to sources of additional information, including some 50 texts, scores of articles from more than 30 different periodicals and many other types of documents issued by both government and private industry Web and Internet addresses for dozens of government and industry resources are also included Cross-references provided in ALL CAPS for ease of use

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